PUBLICATIONS
63. A.T. Odudimu, N.J. Wittenberg. Domain Dissolution in Supported Lipid Bilayers Triggered by Unsaturated Phospholipid Addition. Langmuir 2026, accepted.
62. A.N. Singh, T.T. Ye, N.J. Wittenberg. Advances in Multivariate Analysis of Extracellular Vesicles Using Visible Light-Based Analytical Methods. Nanoscale 2026, 18, 9537 - 9554.
61. B.A. Berger, T.P. Brown, W. Im, N.J. Wittenberg. Microfluidic Generation of Oxidized Phospholipid Gradients in Supported Lipid Bilayers to Examine Scavenger Receptor Interactions. Analytical Chemistry 2025, 97, 20173–20182.
60. D.E. Santa, T.P. Brown, W. Im, N.J. Wittenberg. Atherosclerotic Oxidized Lipids Affect Formation and Biophysical Properties of Supported Lipid Bilayers and Simulated Membranes. Journal of Physical Chemistry B 2024, 128, 11694 - 11704.
59. A.N. Singh, M. Wu, T.T. Ye, A.C. Brown, N.J. Wittenberg. Engineering Planar Gram-Negative Membrane Mimics Using Bacterial Outer Membrane Vesicles. Langmuir 2024, 40, 23289 - 23300.
58. B.A. Berger, H.M. Vietor, D.W. Scott, H. Lee, S. Hashemipour, W. Im, N.J. Wittenberg, K.J. Glover. Physicochemical Properties of Seed Oil Blends and Their Potential for the Creation of Synthetic Oleosomes with Modulated Polarities. ACS Omega 2024, 9, 43193 - 43202.
57. J.L. Cawley, D.E. Santa, A.N. Singh, A.T. Odudimu, B.A. Berger, NJ. Wittenberg. Chaotropic Agent-assisted Supported Lipid Bilayer Formation. Langmuir 2024, 40, 20629 - 20639.
56. A.S. Feix, E.Z. Tabaie, A.N. Singh, N.J. Wittenberg, E.H. Wilson, A. Joachim. An In-depth Exploration of the Multifaceted Roles of EVs in the Context of Pathogenic Single-Cell Microorganisms. Microbiology & Molecular Biology Reviews 2024, 8, e00037-24.
55. A.N. Singh, J.B. Nice, M. Wu, A.C. Brown, N.J. Wittenberg. Multivariate Analysis of Individual Bacterial Outer Membrane Vesicles using Fluorescence Microscopy. Chemical & Biomedical Imaging 2024, 2, 352 - 361.
54. S. Gee, K.J. Glover, N.J. Wittenberg, W. Im. CHARMM-GUI Membrane Builder for Lipid Droplet Modeling and Simulation. ChemPlusChem 2024, 89, e202400013.
53. T.P. Brown, D.E. Santa, B.A. Berger, L. Kong, N.J. Wittenberg, W. Im. CHARMM GUI Membrane Builder for Oxidized Phospholipid Membrane Modeling and Simulation. Current Opinion in Structural Biology 2024, 86, 102813.
52. J.L. Cawley, B.A. Berger, A.T. Odudimu, A.N. Singh, D.E. Santa, A.I. McDarby, A.R. Honerkamp-Smith, N.J. Wittenberg. Imaging Giant Vesicle Membrane Domains with a Luminescent Europium Tetracycline Complex. ACS Omega 2023, 8, 29314 - 29323.
51. G. Ongwae, M. Chordia, J.L. Cawley, B.E. Dalesandro, N.J. Wittenberg, M.M. Pires. Targeting of Pseudomonas aeruginosa Cell Surface via GP12, an Escherichia coli Specific Bacteriophage Protein. Scientific Reports 2022, 12, 721.
50. J.A. Julien, S.G, Mutchek, N.J. Wittenberg, K.J. Glover. Biophysical Characterization of Full-Length Oleosin in Dodecylphosphocholine Micelles. Proteins 2022, 90, 560 - 565.
49. J.L. Cawley, M.E. Blauch, S.M. Collins, J.B Nice, Q. Xie, L.R. Jordan, A.C. Brown, N.J. Wittenberg. Nanoarrays of Individual Liposomes and Bacterial Outer Membrane Vesicles by Liftoff Nanocontact Printing. Small 2021, 17, 2103338.
48. J.A. Julien, A.L. Pellett, S.S. Shah, N.J. Wittenberg, K.J. Glover. Preparation and Characterization of Neutrally-Buoyant Oleosin-Rich Synthetic Lipid Droplets. Biochim Biophys Acta 2021, 1863, 183624.
47. A.M. Baxter, L.R. Jordan, M. Kullappan, N.J. Wittenberg. Tubulation of Supported Lipid Bilayer Membranes Induced by Photosensitized Lipid Oxidation. Langmuir 2021, 37, 5753 - 5762.
46. J.L. Cawley, L.R. Jordan N.J. Wittenberg. Detection and Characterization of Vesicular Gangliosides Binding to Myelin-Associated Glycoprotein on Supported Lipid Bilayers. Analytical Chemistry 2021, 93, 1185 - 1192.
45. A. Barik, X. Chen, L.J. Maher III, A.E. Warrington, M. Rodriguez, S-H. Oh, N.J. Wittenberg. Nanogap Dielectrophoresis Combined with Buffer Exchange for Detecting Protein Binding to Trapped Bioparticles. Colloids and Surfaces A 2021, 611, 125829.
44. A.V. Pisapati, Y. Wang, M.E. Blauch, N.J. Wittenberg, X. Cheng, X.F. Zhang. Characterizing Single Molecule Conformational Changes Under Shear Flow with Fluorescence Microscopy. J Vis Exp 2020, 155, e60784.
43. M. Vala, C.T. Ertsgaard, N.J. Wittenberg, S-H. Oh. Plasmonic Sensing on Symmetric Nanohole Arrays Supporting High-Q Hybrid Modes and Reflection Geometry. ACS Sensors 2019, 4, 3265 - 3274.
42. L.R. Jordan, M.E. Bauch, A.M. Baxter, J.L. Cawley, N.J. Wittenberg. Influence of Brain Gangliosides on the Formation and Properties of Supported Lipid Bilayers. Colloids and Surfaces B: Biointerfaces 2019, 183, 110442.
41. A.M. Baxter, N.J. Wittenberg. Excitation of Fluorescent Lipid Probes Accelerates Supported Lipid Bilayer Formation via Photosensitized Lipid Oxidation. Langmuir 2019, 35, 11542 - 11549.
40. Y-S. Ryu, H. Yun, T. Chung, J-H. Suh, S. Kim, K. Lee, N.J. Wittenberg, S-H. Oh, B. Lee, S-D. Lee. Kinetics of Lipid Raft Formation at Lipid Monolayer-Bilayer Junction Probed by Surface Plasmon Resonance. Biosensors & Bioelectronics 2019, 142, 111568.
39. Y-S. Ryu, L.R. Jordan, N.J. Wittenberg, S.M. Kim, D. Yoo, C. Jeong, A.E. Warrington, M. Rodriguez, S-H. Oh, S-D. Lee. Curvature Elasticity-Driven Leaflet Asymmetry and Inter-leaflet Raft Coupling in Supported Membranes. Advanced Materials Interfaces 2018, 5, 1801290.
38. M. Vala, L.R. Jordan, A.E. Warrington, L.J. Maher III, M. Rodriguez, N.J. Wittenberg, S-H. Oh. Surface plasmon resonance sensing on naturally derived membranes: A remyelination-promoting human antibody binds myelin with extraordinary affinity. Analytical Chemistry 2018, 90, 12567 - 12573.
37. C.T. Ertsgaard, N.J. Wittenberg, D.J. Klemme, A. Barik, W-C. Shih, S-H. Oh. Integrated Nanogap Platform for Sub-Volt Dielectrophoretic Trapping and Real-Time Raman Imaging of Biological Nanoparticles. Nano Letters 2018, 18, 5946-5953.
36. C. Lin, E.R. Stedronsky, L.R. Jordan, N.J. Wittenberg, S.L. Regen. A Plug and Socket Approach for Tightening Polyelectrolyte Multilayers. Chemical Communications 2018, 54, 9769-9772.
35. D. Rodrigo, A. Tittl, N. Ait-Bouziad, A. John-Herpin, O. Limaj, C. Kelly, D. Yoo, N.J. Wittenberg, S-H. Oh, H.A. Lashuel, H. Altug. Resolving Molecule-Specific Information in Dynamic Lipid Membrane Processes with Multi-Resonant Infrared Metasurfaces. Nature Communications 2018, 9, 2160.
34. Y-S. Ryu, N.J. Wittenberg, J-H. Suh, S-W. Lee, Y. Sohn, S-H. Oh, A.N. Parikh, S-D. Lee. Continuity of Monolayer-Bilayer Junctions for Localization of Lipid Raft Microdomains in Model Membranes. Scientific Reports 2016, 6, 26823.
33. S. Kumar, T.W. Johnson, C.K. Wood, T. Qu, N.J. Wittenberg, L.M. Otto, J. Shaver, N.J. Long, R.H. Victora, J.B. Edel, S-H. Oh. Template-Stripped Multifunctional Wedge and Pyramid Arrays for Magnetic Nanofocusing and Optical Sensing. ACS Appl Mater Interfaces 2016, 8, 9319 – 9326.
32. O. Limaj, D. Etezadi, N.J. Wittenberg, D. Rodrigo, D. Yoo, S-H. Oh, H. Altug. Infrared Plasmonic Biosensor for Real-Time and Label-Free Monitoring of Lipid Membranes. Nano Letters 2016, 16, 1502 – 1508.
31. J.A. Jackman, E. Linardy, J. Seo, W.B. Ng, D. Yoo, D.J. Klemme, N.J. Wittenberg, S-H. Oh, N.J. Cho. Plasmonic Nanohole Sensor for Capturing Single Virus-Like Particles towards Virucidal Drug Evaluation. Small 2016, 12, 1159 – 1166.
30. A. Barik, S. Cherukulappurath, N.J. Wittenberg, T.W. Johnson, S-H. Oh. Dielectrophoresis-Assisted Raman Spectroscopy of Intravesicular Analytes on Metallic Pyramids. Analytical Chemistry 2016, 88, 1704 – 1710.
29. B. Wootla, J.O. Watzlawik, N. Stavropoulos, N.J. Wittenberg, H. Dasari, M.A. Abdelrahim, J.R. Henley, S-H. Oh, A.E. Warrington, M. Rodriguez. Recent Advances in Monoclonal Antibody Therapies for Multiple Sclerosis. Exp Opin Biol Ther 2016, 16, 827 – 839.
28. S. Kumar, G.G. Wolken, N.J. Wittenberg, E.A. Arriaga, S-H. Oh. Nanohole Array-Directed Trapping of Mammalian Mitochondria Enabling Single Organelle Analysis. Analytical Chemistry 2015, 87, 11973 – 11977.
27. B. Wootla, J.O. Watzlawik, A.E. Warrington, A. Denic, X. Xu, L.R. Jordan, N.J. Wittenberg, L.M. Papke, L.J. Zoecklein, M.L. Pierce, S-H. Oh, O.H. Kantarci, M. Rodriguez. Natural Monoclonal Antibodies and their Therapeutic Potential for Neurological Diseases. JAMA Neurology 2015, 72, 1346 – 1353.
26. X. Xu, A. Denic, L.R. Jordan, N.J. Wittenberg, A.E. Warrington, B. Wootla, M. Painter, J.O. Watzlawik, L.M. Papke, L.J. Zoecklein, D. Yoo, J. Shaver, S-H. Oh, L. Pease, M. Rodriguez. A Human Natural IgM that Binds to Gangliosides is Therapeutic in Murine Models of Amyotrophic Lateral Sclerosis. Disease Models & Mechanisms 2015, 8, 831 – 842.
25. Y-S. Ryu, D. Yoo, N.J. Wittenberg, L.R. Jordan, S-D. Lee, A.N. Parikh, S-H. Oh. Lipid Membrane Deformation Accompanied by Disk-to-Ring Shape Transformations of Cholesterol-Rich Domains. J Am Chem Soc 2015, 137, 8692 – 8695.
24. Y-S. Ryu, I-H. Lee, J-H. Suh, S.C. Park, S. Oh, L.R. Jordan, N.J. Wittenberg, S-H. Oh, N.L. Jeon, B. Lee, A.N. Parikh, S-D. Lee. Reconstituting Ring-Rafts in Bud-Mimicking Topography of Model Membranes. Nature Communications 2014, 5, 4507.
23. N.J. Wittenberg, T.W. Johnson, L.R. Jordan, X. Xu, A.E. Warrington, M. Rodriguez, S-H. Oh. Formation of biomembrane microarrays with a squeegee-based assembly method. J Vis Exp 2014, 87, e51501.
22. N.J. Wittenberg, B. Wootla, L.R. Jordan, A. Denic, A.E. Warrington, S-H. Oh, M. Rodriguez. Applications of Surface Plasmon Resonance for Characterization of Molecules Important in the Pathogenesis and Treatment of Neurodegenerative Diseases. Exp Rev Neurother 2014, 14, 449 – 463.
21. X. Xu, N.J. Wittenberg, L.R. Jordan, S. Kumar, J.O. Watzlawik, A.E. Warrington, S-H. Oh, M. Rodriguez. A patterned recombinant human IgM guides neurite outgrowth of CNS neurons. Scientific Reports 2013, 3, 2267.
20. J. Jose, L.R. Jordan, T.W. Johnson, S.H. Lee, N.J. Wittenberg, S-H. Oh. Topographically flat substrates with embedded nanoplasmonic devices for biosensing. Adv Funct Mater 2013, 23, 2812 – 2820.
19. A.B. Dahlin, N.J. Wittenberg, F. Höök, S-H. Oh. Promises and challenges of nanoplasmonic structures for refractometric biosensing. Nanophotonics 2013, 2, 83 – 101.
18. S. Kumar, N.J. Wittenberg, S-H. Oh. Nanopore-induced spontaneous concentration for optofluidic sensing and particle assembly. Analytical Chemistry 2013, 85, 971 – 977.
17. N.J. Wittenberg, T.W. Johnson, S-H. Oh. High density arrays of sub-micron spherical supported lipid bilayers. Analytical Chemistry 2012, 84, 8207 – 8213.
16. S.H. Lee, N.C. Lindquist, N.J. Wittenberg, L.R. Jordan, S-H. Oh. Real-time full-spectral imaging and affinity measurements from 50 parallel channels using nanohole surface plasmon resonance. Lab Chip 2012, 12, 3882 – 3990.
15. N.J. Wittenberg, H. Im, X. Xu, B. Wootla, J. Watzlawik, A.E. Warrington, M. Rodriguez, S-H. Oh. High-affinity binding of remyelinating natural autoantibodies to myelin-mimicking lipid bilayers revealed by nanohole surface plasmon resonance. Analytical Chemistry 2012, 84, 6031 – 6039.
14. H. Im, N.J. Wittenberg, N.C. Lindquist, S-H. Oh. Atomic Layer Deposition (ALD): A Versatile Technique for Plasmonics and Nanobiotechnology. J Mater Res 2012, 27, 663 – 671.
13. N.J. Wittenberg, H. Im, T.W. Johnson, X. Xu, A.E. Warrington, M. Rodriguez, S-H. Oh. Facile assembly of micro- and nanoarrays for sensing with natural cell membranes. ACS Nano 2011 5, 7555 – 7564.
12. H. Im, S.H. Lee, N.J. Wittenberg, T.W. Johnson, N.C. Lindquist, P. Nagpal, D.J. Norris, S-H. Oh. Template-stripped smooth Ag nanohole arrays with silica shells for surface plasmon resonance biosensing. ACS Nano 2011, 5, 6244 – 6253.
11. K.C. Bantz, A.F. Gerard, N.J. Wittenberg, H. Im, O. Kurtulus, S.H. Lee, N.C. Lindquist, S-H. Oh, C.L. Haynes. Recent Progress in SERS Biosensing. Phys Chem Chem Phys 2011, 13, 11551 – 11567.
10. H. Im, N.J. Wittenberg, A. Lesuffleur, N.C. Lindquist, S-H. Oh. Membrane protein biosensing with plasmonic nanopore arrays and pore spanning lipid membranes. Chemical Science 2010, 6, 688 – 696.
9. N.J. Wittenberg, C.L. Haynes. Using nanoparticles to push the limits of detection. Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology 2009, 1, 237 – 254.
8. S. Ge, N.J. Wittenberg, C.L. Haynes. Real-time and quantitative detection of chemical messenger secretion from single platelets. Biochemistry 2008, 47, 7020 – 7024.
7. N.J. Wittenberg, L. Zheng, N. Winograd, A.G. Ewing. Short-chain linear alcohols accelerate membrane distension in a liposome model of exocytosis. Langmuir 2008, 24, 2637 – 2642.
6. L.A. Sombers, N.J. Wittenberg, M.M. Maxson, K.L. Adams, A.G. Ewing. High osmolarity and L-DOPA augment release through the fusion pore in PC12 cells. ChemPhysChem 2007, 8, 2471 – 2477.
5. N.J. Wittenberg, A.G. Ewing. Electrochemistry in and at single biological cells. Handbook of Electrochemistry, pg. 719 – 749, C.G. Zoski, Editor, 2007, Elsevier, Amsterdam.
4. N. Wittenberg, M. Maxson, D. Eves, A.S. Cans, A.G. Ewing. Electrochemistry at the cell membrane/solution interface. Electrochemical Methods for Neuroscience, pg. 285 – 314, A.C. Michael and L.M. Borland, Editors, 2007, CRC Press, Boca Raton.
3. L.A. Sombers, H.J. Hanchar, T.L. Colliver, N. Wittenberg, A.S. Cans, S. Arbault, C. Amatore, A.G. Ewing. The effects of vesicular volume on secretion through the fusion pore in exocytotic release from PC12 cells. J Neurosci 2004, 24, 303 – 309.
2. A.S. Cans, N. Wittenberg, D. Eves, R. Karlsson, A. Karlsson, O. Orwar, A.G. Ewing. Amperometric detection of exocytosis in an artificial synapse. Analytical Chemistry 2003, 75, 4168 – 4175.
1. A.S. Cans, N. Wittenberg, R. Karlsson, L. Sombers, M. Karlsson, O. Orwar, A. Ewing. Artificial cells: unique insights into exocytosis using liposomes and lipid nanotubes. Proc Natl Acad Sci USA 2003, 100, 400 – 404.