We are thrilled to announce that Nate has received an NSF CAREER award for a proposal entitled, "CAREER: Investigating the Molecular Factors that Underlie Myelin-Associated Glycoprotein Binding." Myelin-associated glycoprotein (MAG) is a protein found on the inner myelin membrane, and it is one of a number of proteins that mediate the interaction between myelin and axons. MAG on myelin binds GD1a and GT1b gangliosides as well as Nogo receptor 1 (NgR1) on the axonal membrane.
This 5-year award (2021-2026) will support our research on how cholesterol and membrane phase separation can modulate the interactions between gangliosides and myelin-associated glycoprotein (MAG). Additionally, we will use a variety of analytical techniques to probe how the stoichiometry of the NgR1/p75/LINGO-1 receptor complex modulates the binding of MAG to NgR1.
This award will also support the development of an active learning-based upper level course on biosensors and bioanalytical chemistry, as well as teaching laboratory modules on lipid membrane-based biosensors.